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1.


   
    Organelle Contact Sites [[electronic resource] :] : from Molecular Mechanism to Disease / / ed.: Tagaya, Mitsuo., Simmen, Thomas. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 257 p. 43 illus., 42 illus. in color. - Б. ц.
    Зміст:
Part 1: Overview of Organelle Contacts --
Chapter 1: Organelle Communication at Membrane Contact Sites (MCS): From Curiosity to Center Stage in Cell Biology and Biomedical Research --
Part 2: Organization and Roles of Organelle Contact Sites --
Chapter 2: Over Six Decades of Discovery and Characterization of the Architecture at Mitochondria-Associated Membranes (MAMs) --
Chapter 3: Regulation of mitochondrial dynamics and autophagy by the mitochondria-associated membrane --
Chapter 4: Endoplasmic Reticulum-Mitochondria Communication Through Ca2+ signaling: the importance of mitochondria associated membranes (MAMs) --
Chapter 5: Ceramide transport from the endoplasmic reticulum to the trans Golgi region at organelle membrane contact sites --
Chapter 6: Endoplasmic Reticulum - Plasma Membrane cross-talk mediated by the extended synaptotagmins --
Chapter 7: Endoplasmic Reticulum–Plasma membrane contacts regulate cellular excitability --
Chapter 8: The lipid droplet and the endoplasmic reticulum --
Chapter 9: Role of intra- and inter-mitochondrial membrane contact sites in yeast phospholipid biogenesis --
Chapter 10: Discovery and roles of ER-endolysosomal contact sites in disease --
Part 3: Infection and Disease --
Chapter 11: Alzheimer disease --
Chapter 12: Mitochondrial-associated membranes in Parkinson’s disease --
Chapter 13: Role of endoplasmic reticulum-mitochondria communication in type 2 diabetes --
Chapter 14: Mitochondria–endoplasmic reticulum contact sites mediate innate immune responses --
Chapter 15: Hepatitis C Virus Replication --
Chapter 16: Hijacking of Membrane Contact Sites by Intracellular Bacterial Pathogens --
Chapter 17: Alterations in Ca2+ signalling via ER-mitochondria contact site remodelling in cancer.
Рубрики: Cell biology.
   Biochemistry.
   Molecular biology.
   Human physiology.
   Cancer research.
   Immunology.
   Cell Biology.
   Biochemistry, general.
   Molecular Medicine.
   Human Physiology.
   Cancer Research.
   Immunology.
Анотація: This book provides the first comprehensive coverage of the quickly evolving research field of membrane contact sites (MCS). A total of 16 chapters explain their organization and role and unveil the significance of MCS for various diseases. MCS, the intracellular structures where organellar membranes come in close contact with one another, mediate the exchange of proteins, lipids, and ions. Via these functions, MCS are critical for the survival and the growth of the cell. Owing to that central role in the functioning of cells, MCS dysfunctions lead to important defects of human physiology, influence viral and bacterial infection, and cause disease such as inflammation, type II diabetes, neurodegenerative disorders, and cancer. To approach such a multifaceted topic, this volume assembles a series of chapters dealing with the full array of research about MCS and their respective roles for diseases. Most chapters also introduce the history and the state of the art of MCS research, which will initiate discussion points for the respective types of MCS for years to come. This work will appeal to all cell biologists as well as researchers on diseases that are impacted by MCS dysfunction. Additionally, it will stimulate graduate students and postdocs who will energize, drive, and develop the research field in the near future.

Перейти: https://doi.org/10.1007/978-981-10-4567-7

Дод.точки доступу:
Tagaya, Mitsuo. \ed.\; Simmen, Thomas. \ed.\; SpringerLink (Online service)
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2.


   
    Clinical Management of Pulmonary Disorders and Diseases [[electronic resource] /] : монография / ed. Pokorski, Mieczyslaw. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 86 p. - Б. ц.
    Зміст:
Preface --
Chap. 1 Sociodemographic and Clinical Determinants of Quality of Life of Patients with Non-Small Cell Lung Cancer, M. Chabowski, J. Polanski, G. Mazur, D. Janczak, and J. Rosinczuk --
Chap 2 Obstructive Sleep Apnea and Chronic Kidney Disease, J. Yayan, K. Rasche, and A. Vlachou --
Chap 3 Mortality due to Nosocomial Infection with Klebsiella Pneumoniae ESBL+, K. Starzyk-Luszcz, T.M. Zielonka, J. Jakubik, and K. Zycinska --
Chap. 4 Echocardiographic Assessment in Patients with Granulomatosis with Polyangiitis --
K. Zycinska, A. Borowiec, T.M Zielonka, T. Rusinowicz, M. Hadzik-Blaszczyk, M. Cieplak, and K.A. Wardyn --
Chap. 5 Lung Lesions during Fever of Unknown Origin, R. Krupa, T.M. Zielonka, M. Hadzik-Blaszczyk, K.A. Wardyn, and K. Zycinska --
Chap. 6 Importance of GOLD Guidelines for Chronic Obstructive Pulmonary Disease, J. Sadlonova, D. Osinova, E. Rozborilova, O. Osina, E. Novakova, and V. Sadlonova --
Chap. 7 Cardiac Arrhythmias in Patients with Exacerbation of COPD, T. Rusinowicz, T.M. Zielonka, and K. Zycinska --
Chap. 8 Enzymatic activity of Candida spp. from oral cavity and urine in children with nephrotic syndrome, D. Olczak-Kowalczyk, M. Roszkowska-Blaim, M. Dabkowska, E. Swoboda-Kopec, D. Gozdowski, M. Mizerska-Wasiak, U. Demkow, and M. Panczyk-Tomaszewska --
Chap. 9 Thyroid Autoimmunity in Girls with Turner Syndrome, E. Witkowska-Sedek, A. Borowiec, A. Kucharska, K. Chacewicz, M. Ruminska, U. Demkow, and B. Pyrzak --
Chap. 10 Preventive Chair Massage with Algometry to Maintain Psychosomatic Balance in White Collar Workers, A. Cabak, M. Mikicin, M. Lyp, I. Stanislawska, R. Kaczor, and W. Tomaszewski --
index.
Рубрики: Respiratory organs—Diseases.
   Neurosciences.
   Cell biology.
   Pneumology/Respiratory System.
   Neurosciences.
   Cell Biology.
Анотація: The book endeavors to provide a stimulating and thought provoking scientific content to share and exchange new clinical studies and advancements in dealing with pulmonary diseases. The topics vary from clinical to translational research in respiratory diseases such as lung cancer, obstructive sleep apnea, chronic obstructive pulmonary disease, bacterial and fungal infections, lung lesions during febrile maladies, and others. An attempt has been made to show the intertwined relationship between the pulmonary system and other body systems such as kidney, cardiac, or hormonal functions. The ensuing interlocked morbidities, often exacerbating one another, require the coordination of various medical specialties to optimize the diagnostic and therapeutic processes. The knowledge sharing through publications of research and clinical experiences is indispensable to accelerate the innovation spectrum and to continue working on the therapeutic and preventive strategies in chronic pulmonary diseases. The book is addressed to pulmonologists, chest physicians, researchers, and healthcare professionals engaged in patient care.

Перейти: https://doi.org/10.1007/978-3-319-69545-7

Дод.точки доступу:
Pokorski, Mieczyslaw. \ed.\; SpringerLink (Online service)
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3.


   
    Vertebrate Development [[electronic resource] :] : maternal to Zygotic Control / / ed.: Pelegri, Francisco., Danilchik, Michael., Sutherland, Ann. - 1st ed. 2017. - [S. l. : s. n.]. - X, 549 p. 81 illus., 71 illus. in color. - Б. ц.
    Зміст:
Preface --
1. Egg Activation at Fertilization --
2. Controlling the Messenger: Regulated Translation of Maternal mRNAs in Xenopus laevis Development --
3. Regulation of Cell Division --
4. Vertebrate Embryonic Cleavage Pattern Determination --
5. Localization in Oogenesis of Maternal Regulators of Embryonic Development --
6. Vertebrate Axial Patterning: from Egg to Asymmetry --
7. Establishment of the Vertebrate Germ Layers --
8. Mechanisms of Vertebrate Germ Cell Determination --
9. Cell Cycle Remodeling and Zygotic Gene Activation at the Midblastula Transition --
10. Clearance of Parental Products --
Index.
Рубрики: Cell biology.
   Embryology.
   Cell Biology.
   Embryology.
Анотація: This book provides a comprehensive overview of topics describing the earliest steps of fertilization, from egg activation and fertilization to the activation of the zygotic genome, in various studied vertebrate model systems. The contribution of maternal and paternal factors and their role in the early embryo as parental DNA becomes modified and embryonic genes become activated is fundamental to the initiation of embryogenesis in all animal systems. It can be argued that this is a unique developmental period, when information from the parents is compressed to direct the development of the body plan of the entire organism, a process of astounding simplicity, elegance and beauty. In addition to their fundamental scientific interest, many frontiers of biomedicine, such as reproductive biology, stem cells and reprogramming, and the understanding of intergenerational diseases, depend on advances in our knowledge of these early processes. Vertebrate Development: Maternal to Zygotic Control brings together chapters from experts in various disciplines describing the latest advances related to this important developmental transition. Each chapter is a synthesis of knowledge relevant to all vertebrates, with details on specific systems as well as comparisons between the various studied vertebrate models. The editorial expertise encompasses the fields of major vertebrate model systems (mammalian, amphibian and teleost) ensuring a balanced approach to various topics. This unique book—with its combination of in-depth and up-to-date basic research, inter-species comprehensiveness and emphasis on the very early stages of animal development—is essential for research scientists studying vertebrate development, as well as being a valuable resource for college educators teaching advanced courses in developmental biology.

Перейти: https://doi.org/10.1007/978-3-319-46095-6

Дод.точки доступу:
Pelegri, Francisco. \ed.\; Danilchik, Michael. \ed.\; Sutherland, Ann. \ed.\; SpringerLink (Online service)
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4.


   
    Bioprobes [[electronic resource] :] : biochemical Tools for Investigating Cell Function / / ed. Osada, Hiroyuki. - 2nd ed. 2017. - [S. l. : s. n.]. - VIII, 384 p. 173 illus., 10 illus. in color. - Б. ц.
    Зміст:
1. Trends in bioprobe research --
2. Cell proliferation and differentiation --
3. Epigenetics --
4. Apoptosis and autophagy --
5. Adaptive and innate immune Systems --
6. Bioprobes at a glance.
Рубрики: Cell biology.
   Biochemistry.
   Biotechnology.
   Organic chemistry.
   Cell Biology.
   Biochemistry, general.
   Biotechnology.
   Organic Chemistry.
Анотація: This new edition provides the most advanced research using bioprobes on the chemical control of 1) cell cycle and differentiation, 2) epigenetics, 3) apoptosis and autophagy, and 4) immune response. The “bioprobe”, first proposed in the first edition, has become an indispensable tool for chemical biology and has substantially assisted in the investigation of complex biochemical processes of cells. New areas of investigation such as stem cell research, epigenetic research, and autophagy research have rapidly advanced in the past 10 years. Including these new findings, this second edition supplies up-to-date information on the biochemical tools called bioprobes. Data on each bioprobe, such as chemical structure, origin, function, and references, are presented as one item in this volume. Readers will easily find useful information and will be able to determine the appropriate bioprobes to investigate cell functions. The information on bioprobes and their use in research makes this book a valuable source for researchers in diverse fields. Not only scientists in academia but also in the pharmaceutical industries will discover the most important information about small molecules useful for drug discovery.

Перейти: https://doi.org/10.1007/978-4-431-56529-1

Дод.точки доступу:
Osada, Hiroyuki. \ed.\; SpringerLink (Online service)
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5.


   
    Heat Shock Proteins in Veterinary Medicine and Sciences [[electronic resource] :] : published under the Sponsorship of the Association for Institutional Research (AIR) and the Association for the Study of Higher Education (ASHE) / / ed.: Asea, Alexzander A. A., Kaur, Punit. - 1st ed. 2017. - [S. l. : s. n.]. - IX, 398 p. 21 illus., 12 illus. in color. - Б. ц.
    Зміст:
SECTION I: DOMESTIC ANIMALS --
Thermotolerance in Domestic Ruminants: A HSP70 Perspective --
Expression Dynamics of Heat Shock Proteins (HSP) in Livestock under Thermal Stress --
Heat Shock Protein Expression and Implications in Spontaneous Animal Tumors: Veterinary and Comparative Aspects --
Heat Shock Protein as an Adjuvant in Veterinary Vaccines --
SECTION II: POULTRY --
Antioxidant Systems and Vitagenes in Poultry Biology: Heat Shock Proteins --
Heat Shock Protein and Thermal Stress in Chicken --
SECTION III: AQUATIC --
Heat Shock Proteins in Fish Health and Diseases: A Pharmacological Perspective --
Physiological Role of Heat Shock Proteins, Molecular Function and Stress Removal in Fishes --
The Role of Heat Shock Proteins in Response to Extracellular Stress in Aquatic Organisms --
Heat Shock Proteins in Aquaculture Disease Immunology and Stress Response of Crustaceans --
SECTION IV: PARASITES --
Heat Shock Proteins in Parasitic Flatworms --
Heat Shock Proteins: Role, Functions and Structure in Parasitic Helminths --
Heat Shock Proteins and Blood-Feeding in Arthropods --
Heat Shock Proteins in Leptospirosis --
Heat Shock Proteins in Vector-pathogen Interactions: The Anaplasma phagocytophilum Model.
Рубрики: Cell biology.
   Bioinformatics.
   Biophysics.
   Biological physics.
   Biology—Technique.
   Cell Biology.
   Computational Biology/Bioinformatics.
   Biological and Medical Physics, Biophysics.
   Biological Techniques.
Анотація: The book Heat Shock Proteins in Veterinary Medicine and Sciences provides the most comprehensive review on contemporary knowledge on the role of heat shock proteins in veterinary medicine and sciences. Using an integrative approach to understanding heat shock protein physiology, the contributors provide a synopsis of novel mechanisms by which HSP are involved in the regulation of normal physiological and pathophysiological conditions. Key basic and clinical research laboratories from major universities and veterinary hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for veterinary doctors, researchers, postdoctoral fellows and graduate students in the fields of Veterinary Medicine, Animal Physiology, Animal Husbandry, Biotechnology, Molecular Medicine, Microbiology and Pathology.

Перейти: https://doi.org/10.1007/978-3-319-73377-7

Дод.точки доступу:
Asea, Alexzander A. A. \ed.\; Kaur, Punit. \ed.\; SpringerLink (Online service)
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6.


   
    Kidney Development and Disease [[electronic resource] /] : монография / ed. Miller, Rachel K. - 1st ed. 2017. - [S. l. : s. n.]. - XI, 372 p. 51 illus., 50 illus. in color. - Б. ц.
    Зміст:
Part A Model Systems of Kidney Development and Disease --
1 Drosophila Malpighian tubule: A model for understanding kidney development, function and disease --
2 Zebrafish pronephros development --
3 Zebrafish as a model of kidney disease --
4 Use of Xenopus frogs to study renal development/repair --
Part B Cell Renewal, Differentiation and Fate in Nephrogenesis --
5 Tissue-specific p53 functions during kidney development --
6 Growth factor regulation in the nephrogenic zone of the developing kidney --
7 Development and diseases of the collecting ductsystem --
8 Origin and function of the renal stroma in health and disease --
Part C Nephron Morphogenesis and Maintenance --
9 Imaging, analysing and interpreting branching morphogenesis in the developing kidney --
10 Genetic syndromes affecting kidney development --
11 Primary cilia in cystic kidney disease --
12 Inflammation and fibrosis in polycystic kidney disease --
13 Epithelial to mesenchymal transition (EMT) andendothelial to mesenchymal transition (EndMT): Role and implications in kidney fibrosis.
Рубрики: Developmental biology.
   Molecular biology.
   Nephrology.
   Cell biology.
   Developmental Biology.
   Molecular Medicine.
   Nephrology.
   Cell Biology.
Анотація: Kidney Development and Disease brings together established and young investigators who are leading authorities in nephrology to describe recent advances in three primary areas of research. The first section describes the use of animal models as powerful tools for the discovery of numerous molecular mechanisms regulating kidney development. The second section focuses on nephric cell renewal and differentiation, which lead to diverse cell fates within the developing kidney, and discusses diseases resulting from the aberrant regulation of the balance between cell fate decisions. The final section concentrates on morphogenesis of the developing kidney and its maintenance after formation as well as the diseases resulting from failures in these processes. Kidney form and function have been extensively studied for centuries, leading to discoveries related to their development and disease. Recent scientific advances in molecular and imaging techniques have broadened our understanding of nephron development and maintenance as well as the diseases related to these processes. .

Перейти: https://doi.org/10.1007/978-3-319-51436-9

Дод.точки доступу:
Miller, Rachel K. \ed.\; SpringerLink (Online service)
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7.


   
    Extracellular Matrix in Tumor Biology [[electronic resource] /] : монография / ed.: Brekken, Rolf A., Stupack, Dwayne. - 1st ed. 2017. - [S. l. : s. n.]. - IX, 115 p. 23 illus., 22 illus. in color. - Б. ц.
    Зміст:
1. The extracellular matrix of tumors: a focus on fibronectin and fibulin-5 --
2. Internalization of collagen: an important matrix turnover pathway in cancer --
3. Lumican, a Small Leucine-Rich Proteoglycan, and Its Biological Function in Tumor Progression --
4. Versican: Role in Cancer Tumorigenesis --
5. Engineering advanced models of the glioblastoma microenvironment using biomaterials --
6. Breaching and opening basement membrane barriers: the anchor cell leads the way.
Рубрики: Cancer research.
   Immunology.
   Molecular biology.
   Oncology  .
   Proteins .
   Cell biology.
   Cancer Research.
   Immunology.
   Molecular Medicine.
   Oncology.
   Receptors.
   Cell Biology.
Анотація: This volume provides an overview on the influence of Extracellular Matrix (ECM) on tumor progression. It covers topics such as signaling induced by structural ECM proteins including collagen and fibronectin, the control of ECM deposition and the turnover in tumors. Also discussed are the migration of cells through basement membranes and the function of proteoglycans including lumican and veriscan in tumor progression. Biomaterial-based in-vitro models as well as C. elegans models of the tumor microenvironment are used to show how these models can lead to a greater understanding of the disease mechanisms that promote cancer progression. The book addresses researchers working on cancer biology or ECM, and oncologists alike.

Перейти: https://doi.org/10.1007/978-3-319-60907-2

Дод.точки доступу:
Brekken, Rolf A. \ed.\; Stupack, Dwayne. \ed.\; SpringerLink (Online service)
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8.


   
    Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity [[electronic resource] /] : монография / ed. Yoshimura, Akihiko. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 267 p. - Б. ц.
    Зміст:
Regulatory T cells: molecular and cellular basis for immunoregulation --
Overview of LAG-3- expressing, IL-10-producing regulatory T cells --
Regulatory Dendritic Cells --
Role of PD-1 in immunity and diseases --
CTLA-4, an essential immune-checkpoint for T cell activation --
Tim-3, Lag-3, and TIGIT --
SOCS1: regulator of T cells in autoimmunity and cancer --
Mining the complex family of protein tyrosine phosphatases for checkpoint regulators in immunity --
Immune regulation by ubiquitin tagging as checkpoint code --
MicroRNA in Immune Regulation.
Рубрики: Immunology.
   Cancer research.
   Cell biology.
   Immunology.
   Cancer Research.
   Cell Biology.
Анотація: This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to “molecules and cells that negatively regulate T-cell activation”. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases. Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike.

Перейти: https://doi.org/10.1007/978-3-319-68929-6

Дод.точки доступу:
Yoshimura, Akihiko. \ed.\; SpringerLink (Online service)
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9.


   
    Drug Resistance in Bacteria, Fungi, Malaria, and Cancer [[electronic resource] /] : монография / ed.: Arora, Gunjan., Sajid, Andaleeb., Kalia, Vipin Chandra. - 1st ed. 2017. - [S. l. : s. n.]. - XIV, 630 p. 64 illus., 49 illus. in color. - Б. ц.
Рубрики: Drug resistance.
   Cell biology.
   Cancer research.
   Bacteriology.
   Drug Resistance.
   Cell Biology.
   Cancer Research.
   Bacteriology.
Анотація: This book is a compilation of past and recent knowledge in the field of emerging drug resistance. The book covers major aspects of drug resistance in bacteria, fungi, malaria, and cancer. Human survival on earth is constantly threatened by disease and syndrome. From the early days, the aim of research in medicine was to find therapeutic agents that can improve the quality of human life. Although humans are dependent on natural compounds from early days their dependence of drugs increased excessively in last century. The advances in chemistry and biology have helped researchers to identify the drugs that have improved treatment of many diseases. The primary factor for treatment of these diseases is dependent on the efficacy of drugs available. The development of resistance to these drugs is one of the major hindrances. Although there are number of books available on this topic, “drug resistance” biology across kingdoms has never been discussed in a coherent way.

Перейти: https://doi.org/10.1007/978-3-319-48683-3

Дод.точки доступу:
Arora, Gunjan. \ed.\; Sajid, Andaleeb. \ed.\; Kalia, Vipin Chandra. \ed.\; SpringerLink (Online service)
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10.


    Rajagopal, Senthilkumar.
    Calcium Signaling: From Physiology to Diseases [[electronic resource] /] : монография / Senthilkumar. Rajagopal, Ponnusamy, Murugavel. ; . - 1st ed. 2017. - [S. l. : s. n.]. - XVI, 91 p. 19 illus., 17 illus. in color. - Б. ц.
    Зміст:
Foreword --
Preface --
Introduction --
Calcium ion --
Calcium homeostasis --
Second messengers --
Calcium ion in muscle physiology --
Calcium triggering transporters --
Anesthetic action on pain pathway --
Calcium signaling in Neurological disorders --
Calcium channels --
Voltage gated calcium channels and diseases --
Processing of natural products using nanotechnology.
Рубрики: Cell biology.
   Neurology .
   Cardiology.
   Pediatrics.
   Cancer research.
   Cell Biology.
   Neurology.
   Cardiology.
   Pediatrics.
   Cancer Research.
Анотація: This book focuses on disorders of calcium channels and the use of drugs to treat calcium-related disorders and their associated toxicities. In particular, it discusses the role of various natural products and their attributes in preventing problems associated with calcium imbalances. In addition, the book analyzes trends in the processing of natural products using nanotechnology and their implications in calcium-related disorders. Lastly, it explores some of the most promising aspects of research into calcium signalling disorders – which is especially important, given the wide variety of cellular processes that are controlled by calcium ions – and provides a trustworthy source of up-to-date information in this area of research.

Перейти: https://doi.org/10.1007/978-981-10-5160-9

Дод.точки доступу:
Ponnusamy, Murugavel.; Rajagopal, Senthilkumar. \.\; SpringerLink (Online service)
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11.


   
    Translational Research in Breast Cancer [[electronic resource] :] : biomarker Diagnosis, Targeted Therapies and Approaches to Precision Medicine / / ed.: Song, Erwei., Hu, Hai. - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 418 p. 15 illus. in color. - Б. ц.
    Зміст:
Chap. 1 The Dawning of Translational Breast Cancer: from Bench to Bedside --
Chap. 2 Biomarker Studies in Early Detection and Prognosis of Breast Cancer --
Chap. 3 The Preventive Intervention of Hereditary Breast Cancer --
Chap. 4 Predicting and Overcoming Chemotherapeutic Resistance for Breast Cancer --
Chap. 5 Studies on DNA Damage Repair and Precision Radiotherapy for Breast Cancer --
Chap. 6 Targeted Therapies against Growth Factor Signaling in Breast Cancer --
Chap. 7 Targeting Stemness: Implications for Precision Medicine in Breast Cancer --
Chap. 8 Disrupting Tumor Angiogenesis and “the Hunger Games” for Breast Cancer --
Chap. 9 Key Factors in Breast Cancer Dissemination and Establishment at the Bone: Past, Present and Future Perspectives --
Chap. 10 Perspectives of Reprogramming Breast Cancer Metabolism --
Chap. 11 Metabolic Changes during Cancer Cachexia Pathogenesis --
Chap. 12 Cell Cycle Regulation in Treatment of Breast Cancer --
Chap. 13 BRCA Gene Mutations and Poly (ADP-ribose) Polymerase Inhibitors in Triple-negative Breast Cancer --
Chap. 14 Targeting the Epigenome as a Novel Therapeutic Approach for Breast Cancer --
Chap. 15 Progress in Vaccine Therapies for Breast Cancer --
Chap. 16 Tumor Associated Macrophages as Therapeutic Targets for Breast Cancer --
Chap 17 New Approaches in CAR-T Cell Immunotherapy for Breast Cancer --
Chap 18 Immune Checkpoint Blockade in Breast Cancer Therapy.
Рубрики: Cancer research.
   Cell biology.
   Cancer Research.
   Cell Biology.
Анотація: This book offers a comprehensive introduction to translational efforts in breast cancer, addressing the latest approaches to precision medicine based on the current state of understanding of breast cancer.   With the latest developments in breast cancer research, our understanding of the genomic changes and the oncogenic signaling cascade of breast cancer has made considerable strides. Further, the immuno-environment has been demonstrated as the barrier to clinical cancer.     As a result of these two trends, a clearer picture of the molecular landscape of breast cancers has facilitated the development of diagnostic, prognostic and predictive biomarkers for clinical oncology. All these aspects are addressed in this volume, which offers a comprehensive resource for researchers, graduate students and oncologists in cancer research.  .

Перейти: https://doi.org/10.1007/978-981-10-6020-5

Дод.точки доступу:
Song, Erwei. \ed.\; Hu, Hai. \ed.\; SpringerLink (Online service)
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12.


   
    Decoding Neural Circuit Structure and Function [[electronic resource] :] : cellular Dissection Using Genetic Model Organisms / / ed.: Celik, Arzu., Wernet, Mathias F. - 1st ed. 2017. - [S. l. : s. n.]. - XIII, 518 p. 92 illus., 81 illus. in color. - Б. ц.
Рубрики: Neurosciences.
   Human genetics.
   Cell biology.
   Neurosciences.
   Human Genetics.
   Cell Biology.
Анотація: This book offers representative examples from fly and mouse models to illustrate the ongoing success of the synergistic, state-of-the-art strategy, focusing on the ways it enhances our understanding of sensory processing. The authors focus on sensory systems (vision, olfaction), which are particularly powerful models for probing the development, connectivity, and function of neural circuits, to answer this question: How do individual nerve cells functionally cooperate to guide behavioral responses? Two genetically tractable species, mice and flies, together significantly further our understanding of these processes. Current efforts focus on integrating knowledge gained from three interrelated fields of research: (1) understanding how the fates of different cell types are specified during development, (2) revealing the synaptic connections between identified cell types (“connectomics”) using high-resolution three-dimensional circuit anatomy, and (3) causal testing of how iden tified circuit elements contribute to visual perception and behavior.

Перейти: https://doi.org/10.1007/978-3-319-57363-2

Дод.точки доступу:
Celik, Arzu. \ed.\; Wernet, Mathias F. \ed.\; SpringerLink (Online service)
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13.


   
    DNA Replication [[electronic resource] :] : from Old Principles to New Discoveries / / ed.: Masai, Hisao., Foiani, Marco. - 1st ed. 2017. - [S. l. : s. n.]. - XII, 581 p. 94 illus., 87 illus. in color. - Б. ц.
    Зміст:
Preface --
Biography --
Chapter1. Historical Perspective of Eukaryotic DNA Replication --
Chapter2. Regulation of replication origins --
Chapter3. Molecular mechanism for chromatin regulation during MCM loading in mammalian cells --
Chapter4. Initiation of DNA replication at the chromosomal origin of E. coli, oriC --
Chapter5. Initiation of DNA replication in the archaea --
Chapter6. Mechanism of lagging strand DNA replication in eukaryotes --
Chapter7. Functions of multiple clamp and clamp-loader complexes in eukaryotic DNA replication --
Chapter8. Termination of eukaryotic replication forks --
Chapter9. Structure of the MCM2-7 double hexamer and its implications for the mechanistic functions of the Mcm2-7 complex --
Chapter10. Architecture of The Saccharomyces cerevisiae Replisome --
Chapter11. Replication domains: genome compartmentalization into functional replication units --
Chapter12. Rif1-dependent regulation of genome replication in mammals --
Chapter13. G-quadruplexes and DNA replication origins --
Chapter14. Interaction of Rif1 protein with G-quadruplex in control of chromosome transactions --
Chapter15. Chromatin replication and histone dynamics --
Chapter16. The temporal regulation of S phase proteins during G1 --
Chapter17. Roles of SUMO in replication initiation, progression, and termination --
Chapter18. The multiple roles of ubiquitylation in regulating challenged DNA replication --
Chapter19. Regulation of mammalian DNA replication via the ubiquitin-proteasome system --
Chapter20. Coordinating replication with transcription --
Chapter21. Fragility extraordinaire: Unsolved mysteries of chromosome fragile sites --
Chapter22. Cyclin E deregulation and genomic instability --
Chapter23. Replication through repetitive DNA elements and their role in human diseases.
Рубрики: Cell biology.
   Cytogenetics.
   Biochemistry.
   Cell Biology.
   Cytogenetics.
   Biochemistry, general.
Анотація: This book reviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field. The following chapters include genome-wide studies of replication origins and initiation factor binding, as well as the timing of DNA replications, mechanisms of initiation, DNA chain elongation and termination of DNA replication, the structural basis of functions of protein complexes responsible for execution of DNA replication, cell cycle-dependent regulation of DNA replication, the nature of replication stress and cells’ strategy to deal with the stress, and finally how all these phenomena are interconnected to genome instability and development of various diseases. By reviewing the existing concepts ranging from the old principles to the newest ideas, the book gives readers an opportunity to learn how the classical replication principles are now being modified and new concepts are being generated to explain how genome DNA replication is achieved with such high adaptability and plasticity. With the development of new methods including cryoelectron microscopy analyses of huge protein complexes, single molecular analyses of initiation and elongation of DNA replication, and total reconstitution of eukaryotic DNA replication with purified factors, the field is enjoying one of its most exciting moments, and this highly timely book conveys that excitement to all interested readers.

Перейти: https://doi.org/10.1007/978-981-10-6955-0

Дод.точки доступу:
Masai, Hisao. \ed.\; Foiani, Marco. \ed.\; SpringerLink (Online service)
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14.


   
    Mitochondrial DNA and Diseases [[electronic resource] /] : монография / ed.: Sun, Hongzhi., Wang, Xiangdong. - 1st ed. 2017. - [S. l. : s. n.]. - VII, 230 p. 89 illus., 62 illus. in color. - Б. ц.
    Зміст:
How far can mitochondrial DNA drive the disease? --
Mitochondrial DNA in lung cancer --
Approach, application and bioethics of mtDNA sequencing in cancer --
Roles of mitochondrial DNA signaling in immune responses --
Mitochondrial DNA in Telocytes --
Roles of mitochondrial DNA in energy metabolism --
The role of base excision repair in maintaining mitochondrial DNA stability.- Is mitochondrial cell fragility a cell weakness? --
Mitochondrial DNA methylation and related disease --
Beyond deubiquitylation: USP30-mediated regulation of mitochondrial homeostasis --
Metabolic regulation in mitochondria and drug resistance.- Mitochondrial Lon Protease and Cancer --
Regulatory roles of mitochondrial ribosome in lung diseases and single cell biology.-Epithelial mitochondrial dysfunction in lung disease.
Рубрики: Cell biology.
   Human genetics.
   Cell Biology.
   Human Genetics.
Анотація: The book describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the significance of approach, application, and bioethics of mtDNA sequencing.  Authors made a great effort to overview roles of mtDNA signaling pathways, base excision repair, methylation, USP30-mediated regulation, mitochondrial ribosome, autophagy pathways, or ROS-dependent signaling in the pathogenesis, diagnosis, prevention and treatment of diseases. It also demonstrates the importance of basic mitochondrial genetics and the relationship between mutations and disease phenotypes and ageing. This book covers not only the basic information of mtDNA, the relationship of mtDNA and disease, but also mtDNA in stem cell and mitochondria and metabolism etc. The book is written for biological and clinical students and researchers in the field of mtDNA–associated diseases.

Перейти: https://doi.org/10.1007/978-981-10-6674-0

Дод.точки доступу:
Sun, Hongzhi. \ed.\; Wang, Xiangdong. \ed.\; SpringerLink (Online service)
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15.


    Stubler, Sabine.
    Modelling Proteasome Dynamics in a Bayesian Framework [[electronic resource] /] : монография / Sabine. Stubler ; . - 1st ed. 2017. - [S. l. : s. n.]. - XV, 96 p. 30 illus., 10 illus. in color. - Б. ц.
    Зміст:
Structure and Function of the Proteasome --
Approaches to Model Proteasome Dynamics --
Comparison of the Dynamics of Proteasome Subtypes --
Inhibitor Influence on the Catalytic Subunits --
Inhibitor Influence on a Compartmentalised Short Fluorogenic Peptide Model .  .
Рубрики: Immunology.
   Bioinformatics.
   Cell biology.
   Immunology.
   Bioinformatics.
   Cell Biology.
Анотація: Sabine Stubler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model. In a second step, the author extends this model to be able to describe the influence of proteasome inhibitors in in vitro experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor’s transport parameters for strong or isoform-specific inhibition. Contents Structure and Function of the Proteasome Approaches to Model Proteasome Dynamics Comparison of the Dynamics of Proteasome Subtypes Inhibitor Influence on the Catalytic Subunits  Inhibitor Influence on a Compartmentalised Short Fluorogenic Peptide Model  Target Groups Lecturers and students of systems biology, immunology and cell biology Practitioners from the fields of systems biology, immunology and cell biology About the Author Sabine Stubler works as PhD student in the Computational Physiology Group at the Institute of Biochemistry and Biology, University of Potsdam. Her research focus currently is on developing a novel systems pharmacology model.

Перейти: https://doi.org/10.1007/978-3-658-20167-8

Дод.точки доступу:
Stubler, Sabine. \.\; SpringerLink (Online service)
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16.


    Zhang, Xin.
    Biological Effects of Static Magnetic Fields [[electronic resource] /] : монография / Xin. Zhang, Yarema, Kevin., Xu, An. ; . - 1st ed. 2017. - [S. l. : s. n.]. - XI, 220 p. 64 illus., 45 illus. in color. - Б. ц.
    Зміст:
Part 1: Introductory and Background Information --
Chapter 1: Parameters of Magnetic fields --
Chapter 2: Static magnetic fields --
Part 2: Scientific basis for SMF effects on biological systems --
Chapter 3. Impact of SMF on biological molecules --
Chapter 4. Impact of SMF on cells --
Chapter 5. Impact of SMF on animals and other organisms --
Part 3: Opportunities for SMF-based therapies --
Chapter 6. Potential applications of SMF in cancer treatment --
Chapter 7. Potential applications of SMF in other disease treatment.
Рубрики: Cancer research.
   Cell biology.
   Cancer Research.
   Cell Biology.
Анотація: The book summarizes the emerging topic about the effects of SMF on biological samples ranging from single molecules, subcellular compartments, and cells to whole organisms, as well as the potential application of SMF in clinical treatment of cancer and other diseases. With the development and growing popularity of modern appliances, including MRI in the hospitals, the potential impact of magnetic fields on human health is invoking increasing concerns. At the same time, SMF has been used in the clinical treatment of tumors and other diseases for decades. However, there are still some reservations and uncertainties about these treatments, which are largely due to the differential biological effects reported in the literature. These experimental inconsistencies are mainly caused by variations such as different magnetic field types, intensities, treatment time as well as biological samples examined. This volume will help clarify some dilemmas in this field and encourage further investigations in order to achieve a better understanding of the biological effects of SMF, aiming for a rational application of SMF in clinical therapy in the near future. The book is useful for scientists doctors, and students who are interested in magnetic fields and life sciences.

Перейти: https://doi.org/10.1007/978-981-10-3579-1

Дод.точки доступу:
Yarema, Kevin.; Xu, An.; Zhang, Xin. \.\; SpringerLink (Online service)
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17.


    DeKosky, Brandon.
    Decoding the Antibody Repertoire [[electronic resource] :] : high Throughput Sequencing of Multiple Transcripts from Single B Cells / / Brandon. DeKosky ; . - 1st ed. 2017. - [S. l. : s. n.]. - XXVIII, 87 p. 34 illus. - Б. ц.
    Зміст:
Background --
High-throughput Sequencing of the Paired Human Immunoglobulin Heavy and Light Chain Repertoire --
In-Depth Determination and Analysis of the Human Paired Heavy and Light Chain Antibody Repertoire --
Paired VH:VL Analysis of Naive B Cell Repertoires and Comparison to Antigen-Experienced B Cell Repertoires in Healthy Human Donors --
Conclusions and Future Perspectives --
Appendices.
Рубрики: Antibodies.
   Genetic engineering.
   Human genetics.
   Cell biology.
   Biochemistry.
   Antibodies.
   Genetic Engineering.
   Human Genetics.
   Cell Biology.
   Biochemistry, general.
Анотація: This thesis outlines the development of the very first technology for high-throughput analysis of paired heavy and light-chain antibody sequences, opening the door for the discovery of new antibodies and the investigation of adaptive immune responses to vaccines and diseases. By designing two new technologies for sequencing multiple mRNA transcripts from up to 10 million isolated, single cells, the author directly addresses the limitations to provide information on the identity of immune receptor pairs encoded by individual B or T lymphocytes. Previous methods for high-throughput immune repertoire sequencing have been unable to provide such information. The techniques developed in this thesis have enabled comprehensive investigation of human B-cell repertoires and have been applied for the rapid discovery of new human antibodies, to gain new insights into the development of human antibody repertoires, and for analysis of human immune responses to vaccination and disease.

Перейти: https://doi.org/10.1007/978-3-319-58518-5

Дод.точки доступу:
DeKosky, Brandon. \.\; SpringerLink (Online service)
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18.


   
    Blue Biotechnology [[electronic resource] :] : from Gene to Bioactive Product / / ed.: Muller, Werner E. G., Schroder, Heinz C., Wang, Xiaohong. - 1st ed. 2017. - [S. l. : s. n.]. - XI, 314 p. 176 illus., 72 illus. in color. - Б. ц.
    Зміст:
35 Years of Marine Natural Product Research in Sweden: Cool Molecules and Models from Cold Waters --
Major Antimicrobial Representatives from Marine Sponges and/or Their Associated Bacteria --
Discovery and Development of Novel Drugs --
Computer Aided Drug Discovery from Marine Compounds: Identification of the Three-dimensional Structural Features Responsible for Antimalarial Activity --
BlueGenics: Bioactive Natural Products of Medicinal Relevance and Approaches to Their Diversification --
New Target Sites for Treatment of Osteoporosis --
Biocalcite and Carbonic Acid Activators --
Electrospinning of Bioactive Wound Healing Nets --
Entotheonella Bacteria as Source of Sponge-derived Natural Products: Opportunities for Biotechnological Production.
Рубрики: Biochemistry.
   Cell biology.
   Pharmacology.
   Biotechnology.
   Molecular biology.
   Animal genetics.
   Animal Biochemistry.
   Cell Biology.
   Pharmacology/Toxicology.
   Biotechnology.
   Molecular Medicine.
   Animal Genetics and Genomics.
Анотація: This book describes the discovery of molecules from unexploited extreme marine environments, and presents new approaches in marine genomics. It combines the current state of knowledge in marine genomics and advanced natural products’ chemistry to pursue the sustainable production of novel secondary metabolites (lead compounds), as well as pharmacologically active peptides/proteins, with antimicrobial, neuroprotective, anti-osteoporotic, anti-protozoan/anti-plasmodial, anti-ageing and immune-modulating effects. Further, it employs molecular-biology-based approaches and advanced chemical techniques to obtain and to select candidate compounds for pre-clinical and clinical studies.

Перейти: https://doi.org/10.1007/978-3-319-51284-6

Дод.точки доступу:
Muller, Werner E. G. \ed.\; Schroder, Heinz C. \ed.\; Wang, Xiaohong. \ed.\; SpringerLink (Online service)
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19.


   
    SUMO Regulation of Cellular Processes [[electronic resource] /] : монография / ed. Wilson, Van G. - 2nd ed. 2017. - [S. l. : s. n.]. - VIII, 415 p. 41 illus., 26 illus. in color. - Б. ц.
    Зміст:
Preface --
Introduction to Sumoylation --
Part I Molecular Functions --
Roles of Sumoylation in mRNA Processing and Metabolsim --
SUMO and Chromatin Remodeling --
Functions of SUMO in the Maintenance of Genome Stability --
Regulation of Cellular Processes by SUMO: Understudied Topics --
The Molecular Interface Between The SUMO And Ubiquitin Systems --
. SUMO and Nucleocytoplasmic Transport --
SUMO Modification of Ion Channels --
The Roles of SUMO in Metabolic Regulation --
Part II Cell Growth Regulation --
The SUMO Pathway in Mitosis --
Wrestling with Chromosomes: The Roles of SUMO During Meiosis --
Sumoylation in Development and Differentiation --
The Role of Sumoylation in Senescence --
Regulation of Plant Cellular and Organismal Development by SUMO --
SUMO in Drosophila Development --
Part III Diseases --
SUMOylation: Implications for Neurodegenerative Diseases --
Sumoylation and Its Contribution to Cancer --
Sumoylation Modulates the Susceptibility to Type 1 Diabetes --
Sumoylation in Craniofacial Disorders --
Coordination of Cellular Localization-Dependent Effects of Sumoylation in Regulating Cardiovascular and Neurological Diseases --
Viral Interplay with the Host Sumoylation System --
SUMOylation as an Integral Mechanism in Bacterial Infection and Disease Pathogenesis --
Index.
Рубрики: Medicine.
   Proteins .
   Cell biology.
   Posttranslational modification.
   Biomedicine, general.
   Protein Science.
   Cell Biology.
   Posttranslational Modification.
Анотація: This is the second edition of a very well received book that details how the sumoylation system functions and how it modulates numerous cellular activities. SUMO is a post-translational modifier in the ubiquitin super-family that has gained recognition over the last twenty years as an essential and prevalent regulatory molecule. Individual chapters explore the biochemistry, molecular biology, and cell biology of the sumoylation system and its substrate proteins. The book is divided into three themed parts: Molecular Functions (I), Cell Growth Regulation (II), and Diseases (III). Parts I and II focus on the contribution of sumoylation to cellular activities in both the nuclear and cytoplasmic compartments. The nuclear activities covered include nucleic acid metabolism (both RNA and DNA), chromosome structure and replication, and nucleocytoplasmic transport. Cytoplasmic processes presented include regulation of membrane ion channels, general metabolism, and apoptotic signalling. Topics in Part III include the role of sumoylation in developmental abnormalities (craniofacial and cardiovascular), diabetes, neurodegenerative diseases, cancer, and infections with viruses and bacteria. Each of the corresponding chapter authors is an active researcher who has made significant contributions to understanding sumoylation. This second edition provides updates and revisions to most of the original chapters plus adds six new chapters to address important developing areas of sumoylation research. This volume is intended for a scientific audience from undergraduates to independent researchers. The content will serve as both a solid introduction for the novice reader and an in depth treatment for the advanced scholar.

Перейти: https://doi.org/10.1007/978-3-319-50044-7

Дод.точки доступу:
Wilson, Van G. \ed.\; SpringerLink (Online service)
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20.


    Dannheisig, David.
    Impact of Survivin Acetylation on its Biological Function [[electronic resource] /] : монография / David. Dannheisig ; . - 1st ed. 2017. - [S. l. : s. n.]. - XXIII, 104 p. 41 illus., 10 illus. in color. - Б. ц.
    Зміст:
Apoptosis – The Programmed Suicide --
Cancer – The Enemy Inside --
Nucleocytoplasmic Transport– Cellular Navigation --
Biological Function of Survivin --
Protein modification – Make-Up for Proteins --
Cell cycle – Virchow’s Heritage.
Рубрики: Cancer research.
   Biomedical engineering.
   Cell biology.
   Cancer Research.
   Biomedical Engineering/Biotechnology.
   Cell Biology.
Анотація: In his research, David Dannheisig investigates the influence of lysine129 acetylation on the biological function of survivin including alteration of nucleocytoplasmic shuttling as well as dimerization behavior. Since survivin participates in two major hallmarks of oncogenesis, namely cell death inhibition and chromosomal segregation during the cell cycle, it reflects a valuable target in cancer therapy and research. The author establishes proximity-dependent, fluorescence-microscopic methods to quantify the interaction of survivin with the export receptor Crm1 as well as the homodimerization itself. In the future, those systems can be used to examine the feasible effect of chemical modulators which are targeting these interactions in a cellular background. The outcome achieved is an essential step towards the enhancement of potential cancer therapies. Contents Apoptosis – The Programmed Suicide Cancer – The Enemy Inside Nucleocytoplasmic Transport– Cellular Navigation Biological Function of Survivin Protein modification – Make-Up for Proteins Cell cycle – Virchow’s Heritage Target Groups Lecturers, students and researchers in the biological-medical sector Practitioners in the fields of molecular biology, cell biology, fluorescence microscopy, medical biology, protein interaction studies The Author David Dannheisig currently is a student of the International Graduate School in Molecular Medicine (IGradU) pursuing his PhD (Dr. rer. nat) degree at the Institute of Biochemistry and Molecular Biology (iBMB) at Ulm University, Germany.

Перейти: https://doi.org/10.1007/978-3-658-18623-4

Дод.точки доступу:
Dannheisig, David. \.\; SpringerLink (Online service)
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