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Загальна кiлькiсть документiв : 8
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    Bone Toxicology [[electronic resource] /] : монография / ed.: Smith, Susan Y., Varela, Aurore., Samadfam, Rana. - 1st ed. 2017. - [S. l. : s. n.]. - XII, 474 p. 72 illus., 63 illus. in color. - Б. ц.
    Зміст:
Bone Toxicology in Preclinical Drug Testing --
Bone Physiology and Biology --
Study designs and Regulatory Considerations --
Specific Considerations for Bone Evaluations for Pediatric Therapeutics --
Bone Pharmacology and other models in Preclinical Drug Testing --
Methods in Bone Toxicology --
Biochemical Markers and Hormones --
Imaging --
Biomechanics --
Pathology and Histomorphometry --
Integrated System Toxicology --
Bone and Muscle --
Bone and Reproductive System --
Bone and Kidneys --
Bone and Energy Metabolism --
Bone and Immune System --
Bone and Central Nervous System --
Bone and Other Organs.
Рубрики: Pharmacology.
   Pharmaceutical technology.
   Animal models in research.
   Pharmacology/Toxicology.
   Pharmaceutical Sciences/Technology.
   Animal Models.
Анотація: The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments. The book is divided into three parts. The first part describes our current understanding of bone biology and its primary regulatory pathways. Additional chapters address regulatory and study design considerations for incorporating bone end points in toxicology studies, with special consideration being given to juvenile toxicology studies. This is intended to address recent regulatory requirements to evaluate skeletal development for drugs in development for pediatric populations. The second part of the book describes the principal techniques and methods used in bone research; understanding how these end-points are derived is fundamental to their appropriate application. These first two parts of the book provide the background and the means to develop the concepts in part three which describes bone and its interaction with other organ systems. The unique series of chapters in part three, contributed to by key leaders in their respective fields and in bone research, provides a comprehensive collective work. Although constantly evolving, the crosstalk and interaction of the skeleton with several organ systems is now recognized and well documented, such as for the reproductive system, muscle and kidney, while our understanding of the interaction with other organ systems, such as the immune system and CNS, is in its infancy. Recent work highlights the key role of the skeleton in the regulation of energy metabolism and the impact this has on research in metabolic diseases such as obesity and diabetes. The hope is that this book will enlighten many and encourage more to explore the impact of new compounds on the skeleton in the development of effective and safe drugs.

Перейти: https://doi.org/10.1007/978-3-319-56192-9

Дод.точки доступу:
Smith, Susan Y. \ed.\; Varela, Aurore. \ed.\; Samadfam, Rana. \ed.\; SpringerLink (Online service)
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    The Cricket as a Model Organism [[electronic resource] :] : development, Regeneration, and Behavior / / ed. Horch, Hadley Wilson. [et al.]. - 1st ed. 2017. - [S. l. : s. n.]. - IX, 376 p. 106 illus., 62 illus. in color. - Б. ц.
    Зміст:
Preface --
Part I Development and Regeneration --
1 History of cricket biology --
2 Early development and diversity of Gryllus appendages --
3 Leg formation and regeneration --
4 Eye development and photoreception of a hemimetabolous insect, Gryllus bimaculatus --
5 An early embryonic diapause stage and developmental plasticity in the band-legged ground cricket Dianemobius nigrofasciatus --
Part II Physiology, Nervous System, and Behavior --
6 Molecular approach to the circadian clock mechanism in the cricket --
7 Hormonal circadian rhythm in the wing-polymorphic cricket Gryllus firmus: Integrating chronobiology, endocrinology and evolution --
8 Plasticity in the cricket central nervous system --
9 Learning and memory --
10 Neurons and networks underlying singing behaviour --
11 The cricket auditory pathway: neural processing of acoustic signals --
12 Neuromodulators and the control of aggression in crickets --
13 Fighting behavior—Understanding the mechanisms of group size-dependent aggression. --
14 Cercal system-mediated anti-predator behaviors --
15 The biochemical basis of life history adaptation: Gryllus studies lead the way --
16 Reproductive behavior and physiology in the cricket Gryllus bimaculatus --
Part III Experimental Approaches --
17 Protocols for olfactory conditioning experiments --
18 Optical recording methods--How to measure of neural activities with Calcium imaging --
19 Trackball systems for analyzing cricket phonotaxis --
20 Synthetic approaches for observing and measuring cricket behaviors --
21 Protocols in the cricket --
BM Index.
Рубрики: Animal models in research.
   Behavioral sciences.
   Developmental biology.
   Food—Biotechnology.
   Animal Models.
   Behavioral Sciences.
   Developmental Biology.
   Food Science.
Анотація: This book covers a broad range of topics about the cricket from its development, regeneration, physiology, nervous system, and behavior with remarkable recent updates by adapting the new, sophisticated molecular techniques including RNAi and other genome editing methods. It also provides detailed protocols on an array of topics and for basic experiments on the cricket. While the cricket has been one of the best models for neuroethological studies over the past 60 years, it has now become the most important system for studying basal hemimetabolous insects. The studies of Gryllus and related species of cricket will yield insight into evolutionary features that are not evident in other insect model systems, which mainly focus on holometabolous insects such as Drosophila, Tribolium, and Bombyx. Research on crickets and grasshoppers will be important for the development of pest-control strategies, given that some of the most notorious pests also belong to the order Orthoptera. At the same time, crickets possess an enormously high “food conversion efficiency”, making them a potentially important food source for an ever-expanding human population. This volume provides a comprehensive source of information as well as potential new applications in pest management and food production of the cricket. It will inspire scientists in various disciplines to use the cricket model system to investigate interesting and innovative questions.

Перейти: https://doi.org/10.1007/978-4-431-56478-2

Дод.точки доступу:
Horch, Hadley Wilson. \ed.\; Mito, Taro. \ed.\; Popadic, Aleksandar. \ed.\; Ohuchi, Hideyo. \ed.\; Noji, Sumihare. \ed.\; SpringerLink (Online service)
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    Reznikova, Zhanna.
    Studying Animal Languages Without Translation: An Insight from Ants [[electronic resource] /] : монография / Zhanna. Reznikova ; . - 1st ed. 2017. - [S. l. : s. n.]. - VIII, 92 p. 25 illus., 15 illus. in color. - Б. ц.
    Зміст:
Communication, speech and language in human- and non-human animals. The complexity of communication systems and intelligence in animals --
Intelligent communication: can animals exchange meaningful messages? --
Cracking animals codes --
Direct dialogs with animals by means of intermediary languages --
Ants and Bits --
Why bits? Information Theory as a tool for studying natural communication systems --
Why ants? Reliable agents for information transmission --
Ants on the Binary Tree --
The entropy – based approach --
The Kolmogorov Complexity-based approach --
Ants can compress information --
Numerical competence in animals with an insight from ant “language” --
Criteria of numerical competence for comparative studies --
Quantitative judgments in animals --
Advanced numerical abilities --
Information Theory as a tool for studying wild arithmetic on the base of their own communications --
An insight from ant “language”: flexibility of communication as a basis for arithmetic skills.
Рубрики: Animal physiology.
   Animal models in research.
   Coding theory.
   Information theory.
   Invertebrates.
   Neurobiology.
   Animal Physiology.
   Animal Models.
   Coding and Information Theory.
   Invertebrates.
   Neurobiology.
Анотація: The Author of this new volume on ant communication demonstrates that information theory is a valuable tool for studying the natural communication of animals. To do so, she pursues a fundamentally new approach to studying animal communication and “linguistic” capacities on the basis of measuring the rate of information transmission and the complexity of transmitted messages. Animals’ communication systems and cognitive abilities have long-since been a topic of particular interest to biologists, psychologists, linguists, and many others, including researchers in the fields of robotics and artificial intelligence. The main difficulties in the analysis of animal language have to date been predominantly methodological in nature. Addressing this perennial problem, the elaborated experimental paradigm presented here has been applied to ants, and can be extended to other social species of animals that have the need to memorize and relay complex “messages”. Accordingly, the method opens exciting new dimensions in the study of natural communications in the wild.

Перейти: https://doi.org/10.1007/978-3-319-44918-0

Дод.точки доступу:
Reznikova, Zhanna. \.\; SpringerLink (Online service)
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    Banerjee, Ena Ray.
    Perspectives in Translational Research in Life Sciences and Biomedicine [[electronic resource] :] : translational Outcomes Research in Life Sciences and Translational Medicine, Volume 2 / / Ena Ray. Banerjee ; . - 1st ed. 2017. - [S. l. : s. n.]. - XII, 132 p. 32 illus., 22 illus. in color. - Б. ц.
    Зміст:
Chapter 1: Tissue Engineering and Nuances of Regenerative Medicine --
Chapter 2: Nanoparticles as anti-inflammatory drug and vehicle --
Chapter 3: Novel Combinatorial Probiotics in Therapy and Prophylaxis --
Chapter 4: Bioprospecting and Bioresource --
Chapter 5: Pharmacogenomics and Molecular Diagnostics --
Chapter 6: Nutraceutical- Prophylactic and Therapeutic Role of Functional Food in Health.
Рубрики: Regenerative medicine.
   Tissue engineering.
   Molecular biology.
   Gene therapy.
   Animal models in research.
   Medical biochemistry.
   Regenerative Medicine/Tissue Engineering.
   Molecular Medicine.
   Gene Therapy.
   Animal Models.
   Medical Biochemistry.
Анотація: This book is a collation of translational research outcomes in the area of life research, which was formerly used mainly for academic pursuits. The studies described focus on innovative interdisciplinary approaches to unraveling problems in life sciences and biomedicine using biodiversity exploration and green technology. The techniques and models presented offer a ready reckoner for researchers in academic institutions and industry, and also provide valuable insights into fundamental research. The book discusses topics such as tissue engineering to create lineage-specific cells for tissue-specific regeneration; how combination cultures of commensalistic bacteria can help boost immunity; development of functional food from natural products from plant, animal, and microbial sources in the nutraceuticals domain; as well as synthesis and mechanisms in nanomedicine and nanoscaffolds in biomedicine. The studies and discourses described touch upon topics that explore biodiversity for the development of disease models, toxicity studies, developmental studies, and harvesting of bioactive compounds for alternative income generation and poverty alleviation, and as a result, bring about economic and ecologic sustainability. This multidimensional and multidisciplinary book focuses on tissue-specific targeting by nanodrugs, development of bioengineering formats for cell- based, nutraceutical-based, functional-food-based and antibody-based green therapy designed tackle multifaceted diseases and syndromes.

Перейти: https://doi.org/10.1007/978-981-10-5870-7

Дод.точки доступу:
Banerjee, Ena Ray. \.\; SpringerLink (Online service)
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    Liang, Xin.
    Mechanosensory Transduction in Drosophila Melanogaster [[electronic resource] /] : монография / Xin. Liang, Sun, Landi., Liu, Zhen. ; . - 1st ed. 2017. - [S. l. : s. n.]. - IX, 82 p. 30 illus., 26 illus. in color. - Б. ц.
    Зміст:
Overview of Mechanosensory Transduction --
“Gating-Spring” Model for Mechanotransduction --
Mechanoreceptors in Drosophila melanogaster.- Mechanotransduction in Drosophila mechanoreceptors --
Drosophila Mechanotransduction Channels.
Рубрики: Neurochemistry.
   Biochemistry.
   Animal models in research.
   Neurochemistry.
   Biochemistry, general.
   Animal Models.
Анотація: This book offers an essential introduction for all graduate students and researchers who are working on or interested in mechanotransduction using fruit flies as their model organisms. Designed for accessibility, it follows a simple five-- Chapter structure, beginning with a general introduction to mechanotransduction in physiology (Chapter 1) and some basic considerations on the principles behind mechanotransduction processes (Chapter 2). In turn, Chapters 3, 4 and 5 focus on mechanoreceptors in Drosophila melanogaster. Chapter 3 explains how the fly’s mechanosensitive cells (i.e. mechanoreceptors) contribute to its daily life, while Chapter 4 explores the ultrastructural and mechanical basis for the working mechanisms of various fly mechanoreceptors. Lastly, Chapter 5 elaborates on the structure, function and physiology of mechanosensitive molecules in fly mechanoreceptors. Accordingly, the book provides an overall framework, helping readers understand mechanosensory transduction, from the physiological level to the molecular level.

Перейти: https://doi.org/10.1007/978-981-10-6526-2

Дод.точки доступу:
Sun, Landi.; Liu, Zhen.; Liang, Xin. \.\; SpringerLink (Online service)
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    Comparative Medicine [[electronic resource] :] : disorders Linking Humans with Their Animals / / ed. Jensen-Jarolim, Erika. - 1st ed. 2017. - [S. l. : s. n.]. - XIX, 230 p. 24 illus., 22 illus. in color. - Б. ц.
    Зміст:
1.Diseases of the Nervous System (Josef Finsterer, Monika Bradl) --
2.Diseases of the Circulatory System (Claudia Stollberger, Ivo Volf) --
3.Diseases of the Kidneys (Renate Kain, Maximilian Pagitz) --
4.Diseases of the Gastrointestinal tract (Nicole Luckschander) --
5.Diseases of the Lung (Karin Hufnagl, Franziska Roth-Walter) --
6.Diseases of Skeleton and Bones (Wolfgang Sipos, Peter Pietschmann) --
7.Diseases of Reproduction (Christine Aurich, Isabella Ellinger) --
8.Diseases of the Endocrine System (Florian Zeugswetter) --
9.Diseases of Stress (Lisa-Maria Glenk) --
10.Diseases of Immunity (Franziska Roth-Walter, Erika Jensen-Jarolim) --
11.Diseases of the Skin (tba) --
12.Diseases of Viral infections (Reinhard Kirnbauer, Sabine Brandt, Edmund Hainisch) --
13.Diseases of Bacterial Infections (Gerold Stanek).-14.Diseases of Protozoal infections (Julia Walochnik) --
15.Diseases of Parasitic infections (Herbert Auer, Anja Joachim) --
16.Principles of Animal Law in Medicinal Research (Regina Binder) --
17.Ethics in Medical Research (Herwig Grimm).
Рубрики: Animal models in research.
   Animal physiology.
   Human physiology.
   Internal medicine.
   Veterinary medicine.
   Animal Models.
   Animal Physiology.
   Human Physiology.
   Internal Medicine.
   Veterinary Medicine/Veterinary Science.
Анотація: This book highlights the most significant diseases for humans and their dogs, cats and horses. The examples discussed, which include allergies, osteoporosis, cancer and many more, illustrate that humans and their companion animals may in fact develop similar diseases. The reader - whether expert or interested lay - can thus directly compare between human and animal patients. The animal patient thereby represents a natural disease model, which besides the experimental models, is urgently needed to improve the therapeutic options for both humans and animals.

Перейти: https://doi.org/10.1007/978-3-319-47007-8

Дод.точки доступу:
Jensen-Jarolim, Erika. \ed.\; SpringerLink (Online service)
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    Animal Models of Neurological Disorders [[electronic resource] :] : principle and Working Procedure for Animal Models of Neurological Disorders / / ed.: Bansal, Puneet Kumar., Deshmukh, Rahul. - 1st ed. 2017. - [S. l. : s. n.]. - XVIII, 343 p. 68 illus., 45 illus. in color. - Б. ц.
    Зміст:
Introduction --
Behavioral observation in neurological disorders --
Anesthesia used in experimental laboratory --
Euthanasia procedure used in experimental laboratory --
Animal models of Epilepsy --
Animal models of Alzheimer’s --
Animal models of Parkinson's --
Animal models of Huntington's --
Animal models of Stroke and Traumatic brain injury --
Animal models of Migraine --
Animal models of Antipsychotics (Schizophrenia).
Рубрики: Neurosciences.
   Animal models in research.
   Neurobiology.
   Pharmacology.
   Neurosciences.
   Animal Models.
   Neurobiology.
   Pharmacology/Toxicology.
Анотація: This book introduces undergraduate, postgraduate and research students and scientists to animal models of neurological disorders, along with their working principle and brief procedures. Addressing all the disorders related to the central nervous system (CNS) in a single platform, on the basis of various literature surveys it describes different procedures to induce a single disease with the help of toxins/chemicals. It also includes numerous protocols for inducing single neurological diseases, thus fulfilling an urgent need for a book that makes specific procedures for neurological disorders available, so that specific disease can be induced in laboratories according to the availability of resources. Further, it acquaints readers with the pathological changes that occur in a particular neurological disorder, which reflect specific signs and symptoms of any particular disease, and examines how they affect everyday life. It is a valuable resource for researchers aiming to eradicate or improve neurological disorders by testing the benefits of different drugs.

Перейти: https://doi.org/10.1007/978-981-10-5981-0

Дод.точки доступу:
Bansal, Puneet Kumar. \ed.\; Deshmukh, Rahul. \ed.\; SpringerLink (Online service)
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    Alternatives for Dermal Toxicity Testing [[electronic resource] /] : монография / ed.: Eskes, Chantra., van Vliet, Erwin., Maibach, Howard I. - 1st ed. 2017. - [S. l. : s. n.]. - XX, 592 p. 92 illus., 61 illus. in color. - Б. ц.
    Зміст:
Introduction --
Concepts --
Skin irritation --
Skin corrosion --
Skin sensitization --
UV-induced effects (phototoxicity & photoallergy) --
Skin genotoxicity --
Other exploratory areas of relevance.
Рубрики: Dermatology.
   Pharmacology.
   Animal models in research.
   Dermatology.
   Pharmacology/Toxicology.
   Animal Models.
Анотація: This book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol, possible adaptations, and challenges and opportunities. The closing section addresses exploratory areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, the use of alternative methods for infections and inflammatory diseases, novel complex skin models, and high-throughput screening techniques. Dermal toxicity is an area in which alternatives to the use of animal testing have already gained scientific, industrial, and regulatory acceptance. Practitioners and researchers alike will find Alternatives for Dermal Toxicity Testing to be an ideal source of reliable, up-to-date information on all aspects of the available test methods and likely future directions.

Перейти: https://doi.org/10.1007/978-3-319-50353-0

Дод.точки доступу:
Eskes, Chantra. \ed.\; van Vliet, Erwin. \ed.\; Maibach, Howard I. \ed.\; SpringerLink (Online service)
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